Phenotypic characterization of cells within subcutaneous rheumatoid nodules
نویسندگان
چکیده
منابع مشابه
Subcutaneous Rheumatoid Nodules.
death to give reliable results. The postmortem interval as already defined established fixed limits for the interval and avoided possible overestimation of the amino acid concentration relative to time after death. Analysis of the results showed no evidence that a specific aminoacidopathy is implicated in the aetiology of cot death but has nevertheless improved our understanding of the biochemi...
متن کاملSubcutaneous rheumatoid nodules.
We describe seven children with subcutaneous rheumatoid nodules who had no clinical evidence of rheumatoid arthritis. Only one girl was seropositive for antinuclear factors and had a slightly raised erythrocyte sedimentation rate. Clinical aspects, risks for developing rheumatoid arthritis, and treatment of this entity are discussed.
متن کاملImmunopathology of subcutaneous rheumatoid nodules.
Nodules obtained from five patients with classical seropositive rheumatoid arthritis were studied by an immunofluorescence technique using polyclonal antibodies to IgG, IgA, IgM, C3c, and fibrin, and monoclonal antibodies to the terminal (C5b-9) complement complex (reaction with a neoantigen in C9 revealed during activation), DR antigens, T cells, macrophages, and interdigitating cells. In all ...
متن کاملSubcutaneous nodules in rheumatoid arthritis.
A 29 year old male with rheumatoid arthritis (RA) of 10 years duration presented with multiple subcutaneous nodules of one month duration while on methotrexate (7.5 mg once a week), salazopyrine (1000 mg/day) and methyl prednisolone (4 mg/day). The nodules involved tendons of metacarpophalangeal joints (Figure 1) and base of left great toe (Figure 2), were painless and did not interfere with hi...
متن کاملExpression of the genes facilitating methotrexate action within subcutaneous rheumatoid nodules.
OBJECTIVES We sought further understanding of the association between methotrexate (MTX) therapy and accelerated development of subcutaneous rheumatoid nodules. The objective was to establish expression of genes involved in the transport, metabolism, and mechanism of action of MTX within nodule tissue. We also examined for differences in gene expression between nodules from patients actively re...
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ژورنال
عنوان ژورنال: Arthritis & Rheumatism
سال: 1983
ISSN: 0004-3591,1529-0131
DOI: 10.1002/art.1780261105